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(—)-nicotine produces conditioned place preference in Lewis, but not Fischer 344 rats

✍ Scribed by Bryan Horan; McKenzie Smith; Eliot L. Gardner; Marino Lepore; Charles R. Ashby Jr.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
41 KB
Volume
26
Category
Article
ISSN
0887-4476

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✦ Synopsis

In this study, we sought to determine if Fischer 344 (F344) and Lewis rats showed different conditioned place preference (CPP) responses to subcutaneously administered (2)-nicotine. Lewis rats displayed a CPP response to (2)-nicotine after five pairings, whereas F344 rats showed no preference for nicotine compared to vehicle. After 10 pairings, the F344 rats showed a conditioned place aversion to (2)-nicotine, whereas the Lewis rats still displayed a significant CPP response. These results suggest that the differences in appetitiveness shown between Lewis and F344 rats to other drugs of abuse extend also to (2)-nicotine.

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