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Nicotine potentiation of haloperidol-induced catalepsy: Striatal mechanisms

✍ Scribed by Paul R. Sanberg; Dwaine F. Emerich; Mohamed M. El-Etri; Michael T. Shipley; Marie D. Zanol; David W. Cahill; Andrew B. Norman

Book ID: 113225601
Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 513 KB
Volume: 46
Category: Article
ISSN: 0091-3057
DOI: 10.1016/0091-3057(93)90357-y

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Pretreatment with quipazine, a serotonin agonist, and clomipramine, a selective serotonin neuronal uptake blocker, was found to potentiate the cataleptic effect of haloperidol in a dose-dependent manner in rats. Pretreatment with methysergide, a serotonin antagonist, reduced the cataleptic effect of