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Nicotine-mediated suppression of the retinoic acid metabolizing enzyme CYP26A1 limits the oncogenic potential of breast cancer

✍ Scribed by Makoto Osanai; Gang-Hong Lee


Book ID
108587057
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
434 KB
Volume
102
Category
Article
ISSN
1347-9032

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## Abstract **BACKGROUND:** CYP26A1, together with CYP26B1 and CYP26C1, are key enzymes of all‐__trans__ retinoic acid (RA) inactivation and their specific and restricted expression in developing embryos participate in the fine tuning RA levels. As RA is a critical regulator of gene expression duri