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Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro

✍ Scribed by Kenjiro Ono; Kazuhiro Hasegawa; Masahito Yamada; Hironobu Naiki

Book ID
119408878
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
267 KB
Volume
52
Category
Article
ISSN
0006-3223

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✍ Kenjiro Ono; Kazuhiro Hasegawa; Hironobu Naiki; Masahito Yamada 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB

## Abstract Inhibition of the accumulation of amyloid β‐peptide (Aβ) and the formation of β‐amyloid fibrils (fAβ) from Aβ, as well as the destabilization of preformed fAβ in the central nervous system, would be attractive therapeutic targets for the treatment of Alzheimer's disease (AD). We reporte