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Nicotine attenuates arachidonic acid-induced neurotoxicity in cultured spinal cord neurons

✍ Scribed by Rosario Garrido; Andrzej Malecki; Bernhard Hennig; Michal Toborek

Book ID
113994776
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
891 KB
Volume
861
Category
Article
ISSN
0006-8993

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The neurotoxic effects of oxygen radicals on spinal cord neuron cultures derived from fetal mouse have been studied. Oxygen radicals, superoxide radical and hydrogen peroxide, were generated by adding xanthine oxidase and hypoxanthine in the culture medium. Exposure of neurons to this oxygen radical