## Abstract Preclinical studies, using primarily rodent models, have shown acetylcholine to have a critical role in brain maturation via activation of nicotinic acetylcholine receptors (nAChRs), a structurally diverse family of ligandβgated ion channels. nAChRs are widely expressed in fetal central
Nicotine and lung development
β Scribed by Gert S. Maritz
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 269 KB
- Volume
- 84
- Category
- Article
- ISSN
- 1542-975X
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## Abstract ## BACKGROUND: We have previously shown that the __Hox__ gene __Hoxbβ5__ is necessary for normal mouse lung branching morphogenesis. Abnormal __Hoxbβ5__ regulation causes specific alterations in airway branching. We hypothesized that __Hoxbβ5__ is similarly involved in human lung branc