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Nicotine and Cotinine Up-Regulate Vascular Endothelial Growth Factor Expression in Endothelial Cells

✍ Scribed by Brian S. Conklin; Weidong Zhao; Dian-Sheng Zhong; Changyi Chen


Book ID
117022417
Publisher
American Society for Investigative Pathology
Year
2002
Tongue
English
Weight
529 KB
Volume
160
Category
Article
ISSN
0002-9440

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Vascular endothelial growth factor (VECF) is a 45kDa secreted peptide that has potent mitogenic activity specific for endothelial cells in vitro and the ability to induce a strong angiogenic response in vivo. In the present study, 24 h treatment with VEGF resulted in a stimulation of expression of t