Reversal of p15/INK4b hypermethylation i
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Tobias Berg; Yalin Guo; Mahmoud Abdelkarim; Manfred Fliegauf; Michael Lübbert
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Article
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2007
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Elsevier Science
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English
⚖ 802 KB
In vitro and in vivo, myeloid leukemic and preleukemic cells exhibit variable sensitivity to the antiproliferative and proapoptotic effects induced already at low concentrations of DNA methyltransferase (DNMT) inhibitors. The molecular mechanisms underlying this variable sensitivity of leukemic blas