NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice
✍ Scribed by E. M. Urbańska; E. Drelewska; K. K. Borowicz; P. Błaszczak; Z. Kleinrok; S. J. Czuczwar
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 536 KB
- Volume
- 103
- Category
- Article
- ISSN
- 1435-1463
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As we have previously reported, intraperitoneal injections of NG-nitro-L-arginine methyl ester [L-NAME; a competitive inhibitor of nitric oxide (NO) synthase] before and after the injection of B16 melanoma cells through a tail vein increased experimental pulmonary metastasis, while simultaneous inje
## Abstract **BACKGROUND:** To test whether the differentiating embryo is susceptible to the teratogenic effects of the nitric oxide (NO) synthesis inhibitor N^G^‐nitro‐L‐arginine methyl ester (L‐NAME). **METHODS:** ICR‐(CD‐1) mice received a single intraperitoneal injection of L‐NAME at 90, 150, o