𝔖 Bobbio Scriptorium
✦   LIBER   ✦

NF–κB kinetics predetermine TNF-α sensitivity of colorectal cancer cells

✍ Scribed by Ralf M. Zwacka; Lesley Stark; Malcolm G. Dunlop


Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
263 KB
Volume
2
Category
Article
ISSN
1099-498X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Catalase overexpression impairs TNF-α in
✍ Regine Lüpertz; Yvonni Chovolou; Andreas Kampkötter; Wim Wätjen; Regine Kahl 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 407 KB

## Abstract The pleiotropic cytokine tumor necrosis factor alpha (TNF‐α) can induce apoptosis but also supports cell survival pathways. Among the possible anti‐apoptotic mechanisms of TNF‐α is the activation of the transcription factor NF‐κB. Since reactive oxygen species (ROS) are assumed to contr

KiSS1 suppresses TNFα-induced breast can
✍ Sung-Gook Cho; Dali Li; Lewis J. Stafford; Jian Luo; Melissa Rodriguez-Villanuev 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 324 KB

## Abstract Tumor necrosis factor‐alpha (TNFα) induces cancer development and metastasis, which is prominently achieved by nuclear factor‐kappa B (NF‐κB) activation. TNFα‐induced NF‐κB activation enhances cellular mechanisms including proliferation, migration, and invasion. KiSS1, a key regulator o

Role of IκBα and IκBβ in the biphasic nu
✍ Iris Kemler; Adriano Fontana 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 113 KB 👁 1 views

In infectious diseases of the central nervous system astrocytes respond to inflammatory cytokines like tumor necrosis factor ␣ (TNF␣) by activation of the transcription factor NF-B, mediated by the proteolysis of its inhibitors IB␣ and IB␤. We studied the kinetics of NF-B induction by TNF␣ in primar

Blockage of NF-κB by IKKβ- or RelA-siRNA
✍ Wenshu Chen; Xia Wang; Lang Bai; Xiaomin Liang; Jianguo Zhuang; Yong Lin 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB

## Abstract Ambiguous roles of genotoxic anticancer therapeutic‐induced NF‐κB activation in regulating gene expression (activation or suppression) and apoptosis (anti‐ or pro‐apoptosis) have recently been suggested. In order to clarify this controversy and determine the usefulness of NF‐κB blockage

Role of IKK and oscillatory NFκB kinetic
✍ Ryuichi Fukuyama; Kwok Peng Ng; Muzaffer Cicek; Clare Kelleher; Roxana Niculaita 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 422 KB

## Abstract Nuclear factor kappa B (NFκB) is a central participant in the metastasis and chemoresistance of colorectal cancer (CRC). However, it is not fully understood to what extent NFκB contributes to induction of the metastasis‐associated matrix metalloprotease‐9 (__MMP‐9__) gene and sensitivit

Caspase cleavage product lacking amino-t
✍ Ki-Woo Kim; Byung Ju Kim; Chul-Woong Chung; Dong-Gyu Jo; In-Ki Kim; You-Hyun Son 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB

In response to a diverse array of signals, IkappaBalpha is targeted for phosphorylation-dependent degradation by the proteasome, thereby activating NF-kappaB. Here we demonstrate a role of the cleavage product of IkappaBalpha in various death signals. During apoptosis of NIH3T3, Jurkat, Rat-1, and L