## Abstract Expression of the α~v~β~3~ integrin is required for normal osteoclast function. We previously showed that an evolutionary conserved NFATc1 binding site is required for RANKL induction and NFATc1 transactivation of the human β~3~ promoter. The mechanism conferring specificity for RANKL i
NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation
✍ Scribed by Tania N. Crotti; Merrilee Flannery; Nicole C. Walsh; Joseph D. Fleming; Steven R. Goldring; Kevin P. McHugh
- Book ID
- 116507429
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 513 KB
- Volume
- 372
- Category
- Article
- ISSN
- 0378-1119
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Gene expression is controlled by epigenetic mechanisms such as histone acetylation and methylation, and recent studies have revealed that key developmental steps are regulated by the trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3). Using ChIP sequencing technology combined w
The increased bone resorption observed after estrogen withdrawal is responsible for bone loss and may lead to osteoporosis. The mechanism by which estradiol inhibits bone resorption is known to involve decreased osteoclastogenesis, however, the effect on osteoclast adhesion remains unclear. We exami