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NFATc1 regulation of the human β3 integrin promoter in osteoclast differentiation

✍ Scribed by Tania N. Crotti; Merrilee Flannery; Nicole C. Walsh; Joseph D. Fleming; Steven R. Goldring; Kevin P. McHugh


Book ID
116507429
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
513 KB
Volume
372
Category
Article
ISSN
0378-1119

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## Abstract Expression of the α~v~β~3~ integrin is required for normal osteoclast function. We previously showed that an evolutionary conserved NFATc1 binding site is required for RANKL induction and NFATc1 transactivation of the human β~3~ promoter. The mechanism conferring specificity for RANKL i

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