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NF-κB and STAT3 signaling hubs for lung innate immunity

✍ Scribed by Lee J. Quinton; Joseph P. Mizgerd

Publisher: Springer-Verlag
Year: 2010
Tongue: English
Weight: 265 KB
Volume: 343
Category: Article
ISSN: 0302-766X
DOI: 10.1007/s00441-010-1044-y

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## Abstract Abrogation of apoptosis to sustain cell survival is an essential step in development of cancer. Aberrant activation of signal transcription factors NF‐κB or STAT3, alterations in p53 status, or BCL/BAX family expression have each been reported to affect cell survival in cancer, includin