NF-kB-mediated β1-integrin Overexpression in Radioresistance of Malignant Breast Cells in 3-Dimensional Culture

β1 integrins mediate cell proliferation

β1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1

✍ Hira Lal Goel; Jean M. Underwood; Jeffrey A. Nickerson; Chung-Cheng Hsieh; Lucia 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB

## Abstract The β1 integrins play an important role in the modulation of cancer cell proliferation and tumor growth. We have previously shown that β1 integrins associate with insulin‐like growth factor type 1 receptor (IGF‐IR) and regulate IGF‐stimulated prostate cancer cell proliferation. In the p