Development of the next generation of HI
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Victor Hadi; Yung-Hyo Koh; Tino Wilson Sanchez; Danielle Barrios; Nouri Neamati;
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Article
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2010
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Elsevier Science
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English
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HIV-1 integrase (IN), one of the essential enzymes in HIV infection, has been validated as a target for HIV treatment. While more than 20 drugs have been approved by the FDA to treat HIV/AIDS, only one drug, Raltegravir (1), was approved as an IN inhibitor. The rapid mutation of the virus, which lea