This edited book provides information on emerging fields of next-generation healthcare informatics with a special emphasis on emerging developments and applications of artificial intelligence, deep learning techniques, computational intelligence methods, Internet of medical things (IoMT), optimization techniques, decision making, nanomedicine, and cloud computing. The book provides a conceptual framework and roadmap for decision-makers for this transformation. The chapters involved in this book cover challenges and opportunities for diabetic retinopathy detection based on deep learning applications, deep learning accelerators in IoT and IoMT, health data analysis, deep reinforcement-based conversational AI agent in healthcare systems, examination of health data performance, multisource data in intelligent medicine, application of genetic algorithms in health care, mental disorder, digital healthcare system with big data analytics, encryption methods in healthcare data security, computation and cognitive bias in healthcare intelligence and pharmacogenomics, guided imagery therapy, cancer detection and prediction techniques, medical image processing for coronavirus, and imbalance learning in health care.