## Abstract Next Generation Sequencing represents a powerful tool for detecting genetic variation associated with human disease. Because of the high cost of this technology, it is critical that we develop efficient study designs that consider the tradeβoff between the number of subjects (__n__) and
Next generation deep sequencing and vaccine design: today and tomorrow
β Scribed by Fabio Luciani; Rowena A. Bull; Andrew R. Lloyd
- Book ID
- 118745751
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 681 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0167-7799
No coin nor oath required. For personal study only.
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Tag-based approaches were originally designed to increase the throughput of capillary sequencing, where concatemers of short sequences were first used in expression profiling. New Next Generation Sequencing methods largely extended the use of tag-based approaches as the tag lengths perfectly match w
## Abstract Most common hereditary diseases in humans are complex and multifactorial. Largeβscale genomeβwide association studies based on SNP genotyping have only identified a small fraction of the heritable variation of these diseases. One explanation may be that many rare variants (a minor allel