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Newly identified loci that influence lipid concentrations and risk of coronary artery disease

✍ Scribed by Willer, Cristen J; Sanna, Serena; Jackson, Anne U; Scuteri, Angelo; Bonnycastle, Lori L; Clarke, Robert; Heath, Simon C; Timpson, Nicholas J; Najjar, Samer S; Stringham, Heather M

Book ID
109914709
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
422 KB
Volume
40
Category
Article
ISSN
1061-4036

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Newly identified loci that influence lipid concentrations and risk of coronary artery disease
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To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals and comprising 6,068 individuals specific to our study (1,874 individuals from the FUSION study of type 2 diabetes a

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## Abstract Recently, genome wide association studies (GWAS) have identified a number of single nucleotide polymorphisms (SNPs) as being associated with coronary heart disease (CHD). We estimated the effect of these SNPs on incident CHD, stroke and total mortality in the prospective cohorts of the