New β-amino-α-trifluoromethyl alcohols and their exploration in the synthesis of trifluoromethylated imidazole derivatives
✍ Scribed by Grzegorz Mlostoń; Emilia Obijalska; Heinz Heimgartner
- Book ID
- 113711548
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 347 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0022-1139
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📜 SIMILAR VOLUMES
## Abstract Review: 72 refs.
## Abstract Nucleophilic trifluoromethylation of __α__‐imino ketones **2**, derived from arylglyoxal, with __Ruppert__–__Prakash__ reagent (CF~3~SiMe~3~) offers a convenient access to the corresponding __O__‐silylated __β__‐imino‐__α__‐(trifluoromethyl) alcohols. In a ‘one‐pot’ procedure, by treatm
## Abstract Trifluoromethylated β‐amino alcohols (I) are convenient starting compounds for the synthesis of a variety of trifluoromethylated three‐, five‐ and six‐membered heterocycles.