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New β-amino-α-trifluoromethyl alcohols and their exploration in the synthesis of trifluoromethylated imidazole derivatives

✍ Scribed by Grzegorz Mlostoń; Emilia Obijalska; Heinz Heimgartner


Book ID
113711548
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
347 KB
Volume
132
Category
Article
ISSN
0022-1139

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## Abstract Nucleophilic trifluoromethylation of __α__‐imino ketones **2**, derived from arylglyoxal, with __Ruppert__–__Prakash__ reagent (CF~3~SiMe~3~) offers a convenient access to the corresponding __O__‐silylated __β__‐imino‐__α__‐(trifluoromethyl) alcohols. In a ‘one‐pot’ procedure, by treatm

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## Abstract Trifluoromethylated β‐amino alcohols (I) are convenient starting compounds for the synthesis of a variety of trifluoromethylated three‐, five‐ and six‐membered heterocycles.