No coin nor oath required. For personal study only.
Referring to Table V, it can be seen that Preparations 104, 106 and 107 show a rather close parallelism between the total alkaloids and the M. Em. D. But Preparation 107 does not show the same parallelism. The number of preparations here is too small for any definite conclusions but it does tend to indicate that the total alkaloidal content and the M. Em. D. do not always run parallel.
The need for a more acceptable assay for Gelsemium has again been pointed out and this is further indicated by the differences found in the strengths of the preparations tested. The indication that alkaloidal content and physiological activity are not always parallel further points to this need.
It is indicated from the data obtained in this study that the determination of the minimum emetic dose in pigeons might serve as an adequate measure of physiological activity; however, further study will be necessary to substantiate this belief.
There is an indication that the drug gathered from a cultivated plant in Florida is much more potent than that usually found on the market. This is suggested as a point for further study.
Should the determination of the M. Em. D. prove a satisfactory means of measuring pharmacological activity, the method would possess the following desirable qualities : economy, simplicity (an assistant being unnecessary), rapidity and a definite end-point.
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