✦ LIBER ✦

New Water-soluble pyropheophorbide a derivatives as possible agents for photodynamic therapy of cancer

✍ Scribed by Tomoyuki Ando; Yoko Suzuki; Rieko Geka; Kazuhiro Irie; Koichi Koshimizu; Takeshi Takemura; Susumu Nakajima; Isao Sakata

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 210 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)93440-3

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✦ Synopsis

Five new water-soluble pyroPPBa derivatives, whose vinyl groups at position 2 were converted into hydrophilic groups, were synthesized, and their in vivo tumor retention was measured by the N2-pulsed laser spectrofluorometry method. The results suggested that these derivatives were advantageous to reduce hyperphotosensitivity in skin, a major side effect of photodynamic therapy.

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