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New type of chimeric fusion product between the EWS and ATF1 genes in clear cell sarcoma (malignant melanoma of soft parts)

✍ Scribed by Antonio Pellín; Carlos Monteagudo; Concha López-Ginés; Carmen Carda; Javier Boix; Antonio Llombart-Bosch

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
135 KB
Volume
23
Category
Article
ISSN
1045-2257

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✦ Synopsis

We report a new case of clear cell sarcoma (CCS) harboring the t(12;22)(q13;q12). Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed the presence of a chimeric transcript between the EWS and ATF1 genes, both in primary and metastatic tissue. Sequencing studies disclosed an in-frame fusion between EWS gene codon 265 and ATF1 gene codon 110. This breakpoint has not been reported previously and indicates an important in vivo loss of EWS and ATF1 gene domains, which could be associated with the unusually aggressive behavior of this tumor.

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Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and cutaneous melanoma: exploring the histogenetic relationship between these two clinicopathological entities
✍ Graadt van Roggen, Jacob F.; Mooi, Wolter J.; Hogendoorn, Pancras C. W. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB 👁 1 views

Clear cell sarcoma of tendons and aponeuroses (CCS) has come to be recognized as a distinct histopathological entity in the last three to four decades. It shares a number of histological and ultrastructural features with cutaneous melanoma (MM), occasionally creating diagnostic difficulties with met