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New tumor antigens recognized by T cells

✍ Scribed by Benoît Van den Eynde; Vincent G Brichard

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
845 KB
Volume
7
Category
Article
ISSN
0952-7915

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✦ Synopsis

A series of tumor cell antigens that are recognized by cytolytic T lymphocytes has been characterized this year. Besides the antigens derived from proteins specifically expressed in tumors, many melanoma antigens derive from melanocytic differentiation proteins. In addition, antigens unique to individual tumors result from mutations in ubiquitously expressed genes.

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Several tumor antigens recognized by T cells have now been identified at the molecular level. Various mechanisms can account for their expression: activation of normally silent genes; point mutations; chromosome translocations; and post-translational modifications of proteins. This led to the notion