New Triterpene Saponins from Acanthophyllum pachystegium

✍ Scribed by Mohamed Haddad; Tomofumi Miyamoto; Mohammad Ramezani; Marie-Aleth Lacaille-Dubois

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: German
• Weight: 105 KB
• Volume: 87
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200490019

✦ Synopsis

Abstract

Four new triterpenoid saponins, pachystegiosides A (1), B (2), C (3), and D (4), were isolated from the roots of Acanthophyllum pachystegium K. H. Their structures were elucidated by means of a combination of homo‐ and heteronuclear 2D‐NMR techniques (COSY, TOCSY, NOESY, HSQC, and HMBC) and by FAB‐MS. The new compounds were characterized as 3‐O‐{O‐β‐D‐galactopyranosyl‐(1→2)‐O‐[β‐D‐xylopyranosyl‐(1→3)]‐β‐D‐glucuronopyranosyl}quillaic acid 28‐{O‐β‐D‐xylopyranosyl‐(1→3)‐O‐β‐D‐xylopyranosyl‐(1→4)‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐O‐[3,4‐di‐O‐acetyl‐β‐D‐quinovopyranosyl‐(1→4)]‐β‐D‐fucopyranosyl}ester (1), 3‐O‐{O‐β‐D‐galactopyranosyl‐(1→2)‐O‐[β‐D‐xylopyranosyl‐(1→3)]‐β‐D‐glucuronopyranosyl}quillaic acid 28‐{O‐β‐D‐xylopyranosyl‐(1→3)‐O‐β‐D‐xylopyranosyl‐(1→4)‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐O‐[4‐O‐acetyl‐β‐D‐quinovopyranosyl‐(1→4)]‐β‐D‐fucopyranosyl} ester (2), 3‐O‐{O‐β‐D‐galactopyranosyl‐(1→2)‐O‐[β‐D‐xylopyranosyl‐(1→3)]‐β‐D‐glucuronopyranosyl}quillaic acid 28‐{O‐β‐D‐xylopyranosyl‐(1→4)‐O‐α‐L‐rhamnopyranosyl‐(1→2)‐O‐[4‐O‐acetyl‐β‐D‐quinovopyranosyl‐(1→4)]‐β‐D‐fucopyranosyl} ester (3), and gypsogenic acid 28‐[O‐β‐D‐glucopyranosyl‐(1→2)‐O‐β‐D‐glucopyranosyl‐(1→6)‐O‐β‐D‐glucopyranosyl‐(1→3)‐β‐D‐galactopyranosyl] ester (4).