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New trends in the treatment of bone metastasis

✍ Scribed by Evan T. Keller; Jinlu Dai; June Escara-Wilke; Christopher L. Hall; Kathleen Ignatoski; Russell S. Taichman; Jill Keller

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
87 KB
Volume
102
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Bone metastasis is often the penultimate harbinger of death for many cancer patients. Bone metastases are often associated with fractures and severe pain resulting in decreased quality of life. Accordingly, effective therapies to inhibit the development or progression of bone metastases will have important clinical benefits. To achieve this goal understanding the mechanisms through which bone metastases develop and progress may provide targets to inhibit the metastases. In the past few years, there have been advances in both understanding the mechanisms through which bone metastases develop and how they impact bone remodeling. Additionally, gains in promising clinical strategies to target bone metastases have been developed. In this prospectus, we will discuss some of these advances. J. Cell. Biochem. 102: 1095–1102, 2007. Β© 2007 Wiley‐Liss, Inc.

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