New Technologies for Toxicity Testing

✍ Scribed by Glyn Stacey (auth.), Michael Balls DPhil, Robert D. Combes PhD, Nirmala Bhogal PhD (eds.)

• Publisher: Springer-Verlag New York
• Year: 2012
• Tongue: English
• Leaves: 282
• Series: Advances in Experimental Medicine and Biology 745
• Edition: 1
• Category: Library

✦ Synopsis

The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.

✦ Table of Contents

Front Matter....Pages i-xxviii
Current Developments in Cell Culture Technology....Pages 1-13
Embryonic Stem Cells in Safety Pharmacology and Toxicology....Pages 14-25
Trends in Cell Culture Technology....Pages 26-46
Tissue Engineering in the Development of Replacement Technologies....Pages 47-57
Toxicity Testing of Nanomaterials....Pages 58-75
Physiologically-Based Pharmacokinetic (PBPK) Models in Toxicity Testing and Risk Assessment....Pages 76-95
In Silico Methods for Toxicity Prediction....Pages 96-116
Luminescent Quantum Dots for Molecular Toxicology....Pages 117-137
Engineering Quasi-Vivo® in Vitro Organ Models....Pages 138-153
ECVAM and New Technologies for Toxicity Testing....Pages 154-180
Medium to High Throughput Screening: Microfabrication and Chip-Based Technology....Pages 181-209
The Use of Genomics in Model in Vitro Systems....Pages 210-220
The Use of Integrated and Intelligent Testing Strategies in the Prediction of Toxic Hazard and in Risk Assessment....Pages 221-253
Back Matter....Pages 255-258

✦ Subjects

Pharmacology/Toxicology; Biomedicine general