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New targeted approaches against the ubiquitin–proteasome system in gastrointestinal malignancies

✍ Scribed by Grande, Enrique ;Earl, Julie ;Fuentes, Raquel ;Carrato, Alfredo


Book ID
115525876
Publisher
Expert Reviews
Year
2012
Tongue
English
Weight
700 KB
Volume
12
Category
Article
ISSN
1473-7140

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## Abstract The ubiquitin–proteasome system (UPS) is the major proteolytic pathway that degrades intracellular proteins in a regulated manner. Deregulation of the UPS has been implicated in the pathogenesis of many neurodegenerative disorders like Alzheimer's disease, Parkinson's diseases, Huntingt