New T2 lesions enable an earlier diagnosis of multiple sclerosis in clinically isolated syndromes
✍ Scribed by Catherine M. Dalton; Peter A. Brex; Katherine A. Miszkiel; Kryshani Fernando; David G. MacManus; Gordon T. Plant; Alan J. Thompson; David H. Miller
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 63 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0364-5134
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✦ Synopsis
Abstract
In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium‐enhancing lesions for dissemination in time at a 3‐month follow‐up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients. Ann Neurol 2003;53:673–676