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New synthesis of estradiol from androsta-1,4-diene-3,17-dione

✍ Scribed by L. L. Vasiljeva; P. M. Demin; D. M. Kochev; M. A. Lapitskaya; K. K. Pivnitsky

Publisher
Springer
Year
1999
Tongue
English
Weight
256 KB
Volume
48
Category
Article
ISSN
1573-9171

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## Abstract A biotransformation process using __Mycobacterium__ sp was studied for androsta‐1, 4‐diene‐3,17‐dione (ADD) and androsta‐4‐ene‐3,17‐dione (AD) production from cholesterol. Cholesterol has a poor solubility in water (∼1.8 mg dm^βˆ’3^ at 25 °C), which makes it difficult to use as the substr