✦ LIBER ✦
New synthesis of cis 5-tert-butyl-L-proline via cuprate. Evaluation as a cis proline mimetic in a biological active octapeptide
✍ Scribed by Carine Aubry; Hassan Oulyadi; Guillaume Dutheuil; Jerome Leprince; Hubert Vaudry; Xavier Pannecoucke; Jean-Charles Quirion
- Book ID
- 105360508
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 293 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.690
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✦ Synopsis
Abstract
cis 5‐tert‐butyl‐L‐proline (Cbp) was prepared rapidly and efficiently by the addition of low‐valent tert‐butyl cuprate to an aminal derived from proline. [Cbp^2^, D‐Leu^5^]‐OP was then synthesized, showing a predominant cis peptide bond conformation, as confirmed by NMR. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.