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New sulfur donors for cyanide antagonism

โœ Scribed by Ilona Petrikovics; Kristof Kovacs; Brittany Winner; Madhuri Ancha; Siva Angulakurthi; Maelani Negrito; Marianna Budai; Csaba Jaszberenyi; Gary Rockwood

Book ID
116925664
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
85 KB
Volume
211
Category
Article
ISSN
0378-4274

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Antidotes for cyanide (CN) intoxication include the use of sulfane sulfur donors (SSDs), such as thiosulfate, which increase the conversion of CN to thiocyanate by the enzyme rhodanese. To develop pretreatments that might be useful against CN, SSDs with greater lipophilicity than thiosulfate were sy