Inverse Acyl Phosph(on)ates: Substrates
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Michael J. Morrison; Naixin Li; R.F. Pratt
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Article
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2001
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Elsevier Science
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English
⚖ 155 KB
Acyl phosph(on)ates represent a new class of inhibitors of beta-lactam-recognizing enzymes. Previously described members of this class were aroyl phosph(on)ates. These compounds have been shown to acylate and/or phosphylate the active site serine residue, leading to either transient or essentially i