New strategy for the identification of squamous carcinoma antigens that induce therapeutic immune responses in tumor-bearing mice

Treatment of squamous carcinoma in mice

Treatment of squamous carcinoma in mice with a vaccine enriched for cells that induce immunity to squamous carcinoma—A new vaccination strategy

✍ Amla Chopra; Tae Sung Kim; InSug O-Sullivan; Don Martinez; Edward P. Cohen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 555 KB

## Abstract We report a new vaccination strategy for squamous cell carcinoma (SCC). The vaccine was prepared by transfer of unfractionated DNA‐fragments (25 kb) from squamous carcinoma cells (KLN205, DBA/2 origin (H‐2^d^)) into LM mouse fibroblasts (C3H/He origin; H‐2^k^), a highly immunogenic cell