The Werner syndrome gene (WRN) encodes a novel helicase of 1,432 amino acids. Homozygous mutations, all of which result in the truncation of the protein, lead to Werner syndrome. However, little is known about the role of WRN in ''normal'' aging. We have identified four missense polymorphisms and fo
✦ LIBER ✦
New STR at the D5S373 locus and its relevance in human population studies
✍ Scribed by J.R. Luis; S. Dios; J.C. Carril; R. Herrera; B. Caeiro
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 60 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1042-0533
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## Abstract LCR, a genetic regulatory element, was examined in β‐thalassemia patients who do not show any mutation in the β‐globin genes. We sequenced LCR‐HS2, HS3, and HS4 in samples from 16 such patients from the Indian population and found only one SNP A‐G in the inverted repeat in HS4. A signif