New steroidal alkaloids having a novel seven ring skeleton from fritillaria ussuriensis maxim

✍ Scribed by Yukie Kitamura; Makoto Nishizawa; Koh Kaneko; Mitsuhiko Ikura; Kunio Hikichi; Motoo Shiro; Yuh-Pan Chen; Hong-Yen Hsu

• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 737 KB
• Volume: 45
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)89104-3

✦ Synopsis

Two new steroidal alkaloids having a novel seven ring skeleton, ussurienine (1) and ussurienone (2), were isolated from the HCI-MeOH hydrolyzed alkaloid fraction of fritillaria ussuriensis Maxim. (Ping-bei-mu). Continuous study on the same plant, however,

showed that 1 and 2 were the artifacts derived from ussuriedine (3) and ussuriedinone (4), which were isolated from the free alkaloids fraction. Their structures were elucidated on the basis of spectral data, X-ray crystal analysis and chemical conversion.

An important traditional Chinese medicine "Bei-mu", the dried bulbs of Fritillaria genus (Liliaceae), has been used as antitussive, sedative and expectorant in China.1)