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New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors

✍ Scribed by Clelia Dallanoce; Fabio Frigerio; Giovanni Grazioso; Carlo Matera; Giacomo Luca Visconti; Marco De Amici; Luca Pucci; Francesco Pistillo; Sergio Fucile; Cecilia Gotti; Francesco Clementi; Carlo De Micheli

Book ID
113583146
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
510 KB
Volume
46
Category
Article
ISSN
0223-5234

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Design, Synthesis, and Pharmacological C
Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ2-Isoxazoline Derivatives as Potent and Selective Agonists of α7 Nicotinic Acetylcholine Receptors
✍ Dr. Clelia Dallanoce; Dr. Pietro Magrone; Dr. Carlo Matera; Dr. Fabio Frigerio; 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 640 KB

## Abstract A set of racemic spirocyclic quinuclidinyl‐Δ^2^‐isoxazoline derivatives was synthesized using a 1,3‐dipolar cycloaddition‐based approach. Target compounds were assayed for binding affinity toward rat neuronal homomeric (α7) and heteromeric (α4β2) nicotinic acetylcholine receptors. Δ^2^‐