✍ Scribed by Wen-Shu Wang; Xia Dai; Li-Ya Hong; Peng Lu; Jin-Chao Feng; Yu-Guo Jiao
No coin nor oath required. For personal study only.
From the whole plants of Ligularia duciformis, four new sesquiterpenoids, 3__β__‐acetoxy‐6__β__‐methoxyeremophila‐7(11),9(10)‐dien‐12,8__β__‐olide (1), 3__β__‐acetoxy‐8__α__‐hydroxy‐6__β__‐methoxyeremophila‐7(11),9(10)‐dien‐12,8__β__‐olide (2), 3__β__‐acetoxy‐10__β__‐hydroxy‐6__β__,8__β__‐dimethoxyeremophil‐7(11)‐en‐12,8__α__‐olide (3), and 3__β__‐acetoxy‐6__β__,8__β__,10__β__‐trihydroxyeremophil‐7(11)‐en‐12,8__α__‐olide (4) were isolated. Their structures were established by high‐field NMR techniques (^1^H,^1^H‐COSY, ^13^C‐APT, HMQC, HMBC, and NOESY) and HR‐ESI‐MS analysis, together with comparison of the spectroscopic data with those of structurally related compounds. In addition, the cytotoxicity of the new compounds against human hepatic cancer cells Bel‐7402, human pneumonic cancer cells A‐549, and human colonic cancer cells HCT‐8 were evaluated, the new compounds showed no cytotoxicity against the three tumor cells (all IC~50~ values >200 μM).
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