New sesquiterpene–monoterpene lactone, artemisolide, isolated from Artemisia argyi

✍ Scribed by Jong Han Kim; Hae-Kyung Kim; Sun Bok Jeon; Kwang-Hee Son; Eun Hee Kim; Sung Kwon Kang; Nack-Do Sung; Byoung-Mog Kwon

• Book ID: 104251681
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 181 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01315-1

✦ Synopsis

A new sesquiterpene-monoterpene lactone, artemisolide, was isolated from the aerial parts of Artemisia argyi. The structure of artemisolide was elucidated by spectroscopic data including HMBC and NOESY. The structure was confirmed by X-ray crystallographic analysis. Artemisolide exhibited in vitro cytotoxic activity with GI 50 values of 2-8 mM against cancer cell lines.