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New Sesquiterpene Formamides from the Marine Sponge Axinyssa sp.

✍ Scribed by Wen-Jian Lan; Hong-Ping Wan; Guo-Xi Li; Hou-Jin Li; Yun-Yun Chen; Cheng-Zhu Liao; Ji-Wen Cai

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
211 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Chemical investigation of an extract of the marine sponge Axinyssa sp., collected from the South China Sea, led to the isolation and identification of two new sesquiterpene formamides, (4__R__*,5__R__*,10__R__*)‐4‐formamidoeudesm‐7‐ene (1) and (4__R__*,5__R__*,7__S__*,10__R__*)‐4‐formamidoeudesman‐11‐ol (2), together with the known 4__α__‐formamidogorgon‐11‐ene (3). Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR spectroscopy, high‐resolution ESI‐TOF mass spectrometry, as well as X‐ray single‐crystal diffraction experiments. Possible biosynthetic pathways for 1–3 were also proposed. The human nasopharyngeal cancer cell line CNE‐2, human cervical cancer cell line HeLa, and human normal liver cell line L02 were used to examine the cytotoxic activities of 1–3 in vitro. As the results, 1 showed significant cytotoxic activity against CNE‐2, HeLa, and L02 cell lines with the IC~50~ values of 13.8, 7.5, and 38.0 μg/ml, resp.

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