New Saponins from Phytolacca dodecandra l'HERIT

✍ Scribed by Bruno Domon; Kurt Hostettmann

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: German
• Weight: 424 KB
• Volume: 67
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19840670517

✦ Synopsis

Abstract

Three bidesmosidic saponins (1–3) have been isolated from the methanolic extract of the berries of Phytolacca dodecandra l'HERIT (Phytolaccaceae) by a combination of rotation locular counter‐current chromatography and column chromatography on reversed phase (RP‐8) With MeOH/H~2~O. The structures have been established by ^1^H‐NMR, ^13^C‐NMR, FAB‐MS, and D/CI‐MS, as well as on the basis of acidic and basic hydrolyses. The monodesmosidic saponins 1a–3a obtained after partial hydrolysis with a base exhibit strong molluscicidal activity against the schistosomiasis‐transmitting snail Biomphalaria glabrata. Saponins 1–3, 1a, and 3a are reported for the first time, whereas 2a has been identified previously in the aqueous extract of P. dodecandra berries.