New rapid analysis method demonstrates differences in 6-[18F]fluoro-l-dopa plasma input curves with and without carbidopa and in hemi-MPTP lesioned monkeys
✍ Scribed by Catherine A. McLellan; Doris J. Doudet; Thomas Brücke; Thomas G. Aigner; Robert M. Cohen
- Book ID
- 103922716
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 796 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0883-2889
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✦ Synopsis
Kinetic modeling of the PET tracer 6-[18F]fluoro-L-dopa ([18F]Dopa), used to measure presynaptic dopamine function, requires the accurate determination of the plasma input curve. We have developed a new method that uses alumina extraction preceded by cation and anion exchange resins to determine the parent compound, [18F]Dopa and its critical metabolite 3-O-methyl-6-[18F]fluoro-L-dopa. Using this method we found that carbidopa increases the plasma input of [18F]Dopa while decreasing the rate of metabolite formation, and that previous drug treatment can significantly effect [18F]Dopa metabolism.