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New Pyrimido[5,4-c]cinnolines with Antiplatelet Activities.

✍ Scribed by Klaus Rehse; Hedwig Gonska

Publisher
John Wiley and Sons
Year
2006
Weight
18 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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## Abstract Twenty one new pyrimido[5,4‐c]cinnolines containing different lipophilic moieties (viz. phenyl, 4‐methoxyphenyl, 2‐furanyl, 2‐thienyl) in position 2 and additional basic groups (__e.g.__, alkylaminopropyl, dialkylaminopropyl and cyclohexylaminopropyl) in position 4 of the title ring sys

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## Abstract In the Born test, 23 title compounds were synthesized and investigated for their antiplatelet activities against collagen, ADP, adrenaline, and platelet‐activating factor (PAF) as inducers of the aggregation. Using collagen, three compounds with IC~50~ values below 10 ΞΌM were found (3a,