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New pyrazolo[3,4-b]pyridones as selective A1 adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies

✍ Scribed by Fossa, Paola; Pestarino, Marco; Menozzi, Giulia; Mosti, Luisa; Schenone, Silvia; Ranise, Angelo; Bondavalli, Francesco; Trincavelli, M. Letizia; Lucacchini, Antonio; Martini, Claudia


Book ID
119963396
Publisher
Royal Society of Chemistry
Year
2005
Tongue
English
Weight
390 KB
Volume
3
Category
Article
ISSN
1477-0520

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## Abstract Sixty‐eight new substituted pyrazolo[3,4‐b]pyridine derivatives were synthesized and tested for enriching a library of active A~1~ adenosine receptor (AR) antagonists belonging to the same class. These compounds were also used as an external test set to check the reliability of a 3D QSA