New process for the electrorefining of nickel

• Book ID: 103082804
• Publisher: Elsevier Science
• Year: 1958
• Tongue: English
• Weight: 81 KB
• Volume: 265
• Category: Article
• ISSN: 0016-0032
• DOI: 10.1016/0016-0032(58)90753-1

✦ Synopsis

CURRENT TOl~ICS 433

that among advanced tumor cell populations not only are there tremendous variations in composition, but also that the nature of this variation changes under the influence of such factors as chemotherapy and radiation. "In many cases parts of the cells die and other parts are selected out to thrive under the new conditions. For instance, in an experimental ascites tumor under the influence of amethopterine, a special cell line is selected out, quite different from the original one. This demonstrates that the cytochemical analysis of tumor cell populations provides a way to study the mechanism of 'tumor progression,' a phenomenon which underlies sudden changes in growth rate, reaction to chemotherapy, and so forth.

"For the study of carcinogenesis the possibility of cytochemical population studies seems to be of value. Already, the limited studies made so far have revealed that these very great variances from normal cell populations exist even at early stages of tumor development. Further work may yield deeper understanding of the factors influencing tumor development and provide a diagnostic aid in the cytochemical identification of the very early stages of tumor growth."