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New Practical Synthesis of Indazoles via Condensation of o-Fluorobenzaldehydes and Their O-Methyloximes with Hydrazine

✍ Scribed by Lukin, Kirill; Hsu, Margaret C.; Fernando, Dilinie; Leanna, M. Robert


Book ID
115491142
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
132 KB
Volume
71
Category
Article
ISSN
0022-3263

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Synthesis of 1-aryl-1H-indazoles via the
✍ Jinhua J Song; Nathan K Yee πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 72 KB

1-Aryl-1H-indazoles were synthesized by the palladium-catalyzed intramolecular amination [Pd(OAc) 2 /dppf/tBuONa (150 mol%)/toluene/90Β°C] of the corresponding N-aryl-N%-(o-bromobenzyl)hydrazines. It was further demonstrated that cyclization of [N-aryl-N%-(o-bromobenzyl)-hydrazinato-N%]-triphenylphos