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New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2

✍ Scribed by Magrioti, Victoria; Nikolaou, Aikaterini; Smyrniotou, Annetta; Shah, Ishita; Constantinou-Kokotou, Violetta; Dennis, Edward A.; Kokotos, George


Book ID
120885775
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
611 KB
Volume
21
Category
Article
ISSN
0968-0896

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## Abstract The calcium‐independent form of phospholipase A2 (iPLA2), an enzyme known to generate arachidonic acid (AA), was recently identified as the predominant constitutive phospholipase in the hippocampus. The present study shows that the iPLA2 inhibitor bromoenol lactone, when introduced into