A paramagnetic support exhibiting very high loading capacities is described. The use of this novel support in solid phase organic synthesis and affinity chromatography is presented.
New polyoxyalkyleneamine-grafted paramagnetic supports for solid-phase synthesis and bioapplications
โ Scribed by Irving Sucholeiki; J.Manuel Perez; Patrick D. Owens
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 105 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The synthesis of some novel polyoxyalkyleneamine grafted paramagnetic supports for use in chemical and biological applications is described. These composite supports were synthesized by utilizing power ultrasound to enhance the level of incorporation of certain high molecular weight, polyoxyalkyleneamine (Jeffamine ยฎ ) polymers into the matrix of a chloromethylated paramagnetic support. These new composite paramagnetic supports show excellent expansion properties in both organic solvents and water. The use of these grafted supports for multi-step solid-phase synthesis was then demonstrated by example.
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