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New Polyketides Isolated from Botryosphaeria australis Strain ZJ12-1A

✍ Scribed by Yu-Hang Xu; Chun-Hua Lu; Zhong-Hui Zheng; Yue-Mao Shen

Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
161 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Four new polyketides, botryosphaerones A–D (1–4, resp.), were obtained from the fermentation culture of Botryosphaeria australis strain ZJ12‐1A, together with four known compounds, O‐methylasparvenone (5), 6‐ethyl‐2,7‐dimethoxyjuglon (6) and its monoacetyl derivative 7, and O‐methylaspmenone (8). Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and HR‐Q‐TOF mass spectrometry, and by comparison with reported data. All compounds were evaluated for their cytotoxic and antimicrobial activities in vitro. Only compounds 6 and 7 showed cytotoxic and antimicrobial activities, as already reported.

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