✦ LIBER ✦

New players in the cytokine orchestra of inflammatory bowel disease

✍ Scribed by Massimo C. Fantini; Giovanni Monteleone; Thomas T. MacDonald

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 137 KB
Volume: 13
Category: Article
ISSN: 1078-0998
DOI: 10.1002/ibd.20212

No coin nor oath required. For personal study only.

✦ Synopsis

In both Crohn's disease (CD) and ulcerative colitis, the pathologic process is almost certainly driven by an aberrant local immune response directed against normal components of the bacterial microflora. Mucosal immune cells interact with nonimmune cells such as epithelial cells and fibroblasts to promote tissue damage; cytokines are essential mediators of this cross talk. Accumulating evidence now suggests that interleukin-21 (IL-21), the newest member of the common gamma-chain-dependent cytokine family, is a key component of the inflammatory cascade. IL-21 is highly produced by activated CD4ϩ lymphocytes in the inflamed gut of patients with CD, where it contributes to sustaining the ongoing Th1 inflammation. IL-21 also increases the secretion of extracellular matrix-degrading enzymes by fibroblasts and of MIP-3␣ by epithelial cells. Two other cytokines, IL-27 and IL-32, may also be important in the inflammatory pathways that operate in IBD.

📜 SIMILAR VOLUMES

Bacterial induction of proinflammatory c

Bacterial induction of proinflammatory cytokines in inflammatory bowel disease

✍ Jan-Michael A. Klapproth; Maiko Sasaki 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB 👁 1 views

It has become increasingly clear that inflammatory bowel disease (IBD) develops on the background of genetic defects in the host, conveying an increased susceptibility to an environmental antigen or antigens. The environmental factor implicated in the pathophysiology of gut inflammation, which is un

Cytokine association with bacterial DNA

Cytokine association with bacterial DNA in serum of patients with inflammatory bowel disease

✍ Ana Gutiérrez; Rubén Francés; Amparo Amorós; Pedro Zapater; Marta Garmendia; Moi 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 147 KB 👁 2 views

## Background: The pathogenesis of inflammatory bowel disease (ibd) involves the interaction between genetic susceptibility, mucosal immunity, and intestinal bacteria. bacterial translocation is a common event in these patients and plays an important role in the perpetuation of chronic intestinal i

Allium sativum (garlic) suppresses leuko

Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease

✍ Greg Hodge; Sandy Hodge; Ping Han 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 202 KB

New insights into the role of IL-17 in i

New insights into the role of IL-17 in inflammatory bowel disease

✍ Ansu Mammen Noronha 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 44 KB 👁 2 views

Inflammatory bowel disease in the settin

Inflammatory bowel disease in the setting of autoimmune pancreatitis

✍ Karthik Ravi; Suresh T. Chari; Santhi S. Vege; William J. Sandborn; Thomas C. Sm 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB 👁 1 views

Background: Despite scattered case reports, the prevalence of inflammatory bowel disease (IBD) in patients with autoimmune pancreatitis (AIP) is unknown. We sought to better characterize the putative association between the conditions. Methods: Medical records of 71 patients meeting accepted criteri

Role of diet in the development of infla

Role of diet in the development of inflammatory bowel disease

✍ Christine A. Chapman-Kiddell; Peter S.W. Davies; Lynda Gillen; Graham L. Radford 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB 👁 1 views

The inflammatory bowel diseases (IBDs) are a group of heterogeneous disorders characterized by acute and chronic inflammatory changes in the small or large bowel, or in both. Increasing incidence and prevalence figures for IBD both in the developed and developing world indicate that environmental fa