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New physiological functions for drug-transporting P-glycoproteins?

โœ Scribed by P. Borst; W.J. van Blitterswijk; J. Borst; A.D. Tepper; A.H. Schinkel


Book ID
117764613
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
621 KB
Volume
1
Category
Article
ISSN
1368-7646

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Kinetic analyses for species differences
โœ Miki Katoh; Naoto Suzuyama; Toshiyuki Takeuchi; Sumie Yoshitomi; Satoru Asahi; T ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 199 KB

P-glycoprotein (P-gp) plays an important role in the pharmacokinetics of drugs. There is little information on the species differences in P-gp-mediated drug transport activity. The purpose of the present study was to clarify the differences in the kinetic parameters and the existence of species diff