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New Photolabile Protecting Groups in Nucleoside and Nucleotide Chemistry—Synthesis, Cleavage Mechanisms and Applications

✍ Scribed by Giegrich, H.; Eisele-Bühler, S.; Hermann, Chr; Kvasyuk, E.; Charubala, R.; Pfleiderer, W.


Book ID
120530815
Publisher
Taylor and Francis Group
Year
1998
Tongue
English
Weight
408 KB
Volume
17
Category
Article
ISSN
0732-8311

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The amino functions of the common 2'-deoxyribo-and ribonucleosides were blocked by the (2cyanoethoxy)carbonyl group on treatment with 2-cyanoethyl carbonochloridate (5) or 1-[(2-cyanoethoxy)carbonyl]-3-methyl-1H-imidazolium chloride (6) leading to 7, 18, 8, 19, 9, and 20. In 2'-deoxyguanosine, the a